In 2015 , the opioid epidemic cost the US more than 500 billion dollars.
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Source 1:
The Council of Economic Advisers. The Underestimated Cost of the Opioid Crisis. Washington, DC: Executive Office of the President; 2017. https://www.whitehouse.gov/sites/whitehouse.gov/files/images/The%20Underestimated%20Cost%20of%20the%20Opioid%20Crisis.pdf