Fact
Research shows that if you regularly use nicotine it can disrupt the cerebral dopamine pathway, amplify stress sensitivity and distort coping mechanisms that buffer against depressive symptoms.
Source 1:
Bi-directional associations of electronic and combustible cigarette use onset patterns with depressive symptoms in adolescents. William V. Lechner, Tim Janssen, Christopher W. Kahler, Janet Audrain-McGovern, and Adam M. Leventhal